Which virus causes disease that affects the liver?

The virus that causes disease affecting the liver is hepatitis, specifically hepatitis viruses like Hepatitis A, B, and C. These viruses specifically target liver cells, leading to inflammation and various liver-related issues including jaundice, fatigue, and more severe complications such as liver cirrhosis or liver cancer over time. Hepatitis is a well-known condition where the liver is compromised due to viral infection, and it is categorized into different types based on the specific virus that causes it, each with distinct transmission routes and health implications.

The other options refer to viruses that affect different systems and do not primarily target the liver. HIV primarily affects the immune system, influenza targets the respiratory system, and herpes viruses lead to infections in skin and mucous membranes rather than the liver. Thus, hepatitis distinctly stands out as the virus that directly impacts liver health.